Research and treatment news
Longer articles are placed here.
Date: Wed, 04 Aug 1999 20:41:37 -0400
From: Midas Gold <firstname.lastname@example.org>
Subject: Re: Nobody Likes Me, Everybody Hates Me...
More on worms, with an SCD-friendly twist at the end...
(New Scientist article)
REGULAR DOSES OF WORMS might rid people of inflammatory bowel disease, say researchers in Iowa. They believe this distressing condition, which is increasingly common in the developed world, is caused by the absence of intestinal parasites. "We're living in sterile boxes, breathing sterile air and drinking sterile water," says Joel Weinstock, who led the research.
Weinstock and his colleagues at the University of Iowa have already fed six sufferers eggs that hatched and developed into parasitic worms. The results were so dramatic that they are planning a larger trial this autumn. Between the second and third week after treatment, five of the six patients went into complete remission," says Weinstock. A single dose of worms eased symptoms for about a month.
Inflammatory bowel disease--an umbrella term for ulcerative colitis and Crohn's disease--appears to be caused by an overactive immune system. Symptoms include diarrhoea, abdominal pain, bowel obstruction and bleeding.
Weinstock noticed that the rise in inflammatory bowel disease was preceded by a decline in intestinal worm infections. Seventy years ago, he says, 40 per cent of American children had worms such as Ascaris lumbricoides, which grow up to 20 centimetres long. As recently as the 1940s, many were infected with smaller whipworms (Trichuris trichuria). "By the 1960s, kids no longer had it," says Weinstock.
"The worms living in the gastrointestinal tract have been with us for 3 million years or longer," he says. "Our immune systems have grown used to their presence." And without such parasites, Weinstock believes the immune system is more likely to produce powerful inflammatory agents such as gamma-interferon, which fire up the activity of white blood cells called macrophages. "As we've de-wormed, people have developed immune systems which are not damped," he says.
The six patients in the initial trial were chosen because steroids and other drugs designed to dampen down the immune system had not helped. Working with his colleagues David Elliott and Robert Summers, Weinstock gave each patient a drink containing microscopic eggs of a species of intestinal worm that doesn't normally infect people. Although these worms can survive in the human gut, growing to about 1 centimetre, they cannot reproduce and are eliminated after a couple of months.
Balfour Sartor, an expert on inflammatory bowel disease at the University of North Carolina in Chapel Hill, is intrigued by Weinstock's experiment. "It's an appealing way of using something that's of fairly low toxicity to treat a set of diseases that for now we don't have a cure for," he says. Sartor is himself experimenting with Lactobacillus and Bifidobacterium gut bacteria, again with the idea that they may have dampening effects on the immune system.
However, there is still a long way to go before doses of worms or bacteria emerge as an accepted treatment for inflammatory bowel disease. Larger controlled trials are needed to show that the results obtained so far aren't merely due to the placebo effect.
- end of quoted article -
Date: Wed, 04 Aug 1999 19:31:49 -0400
From: Teresa Anderson-Little <email@example.com>
Subject: SCD - good diet!
Protein-Rich Diets May Reduce Heart Disease Risk
(The Medical Tribune) - Contradicting the theory that high- protein diets may promote heart disease, researchers have found that a menu rich in animal and vegetable proteins may actually cut heart-disease risk.
Date: Mon, 27 July 1999
Loren Cordain's article "Cereal Grains: Humanity's Double Edged Sword" in World Review of Nutrition & Dietetics, 1999, no 84, page 19-73, and in the book 'Evolutionary Aspects of Nutrition and Health - Diet, Exercise, Genetics and Chronic Disease' is worth reading! A summary of the book can be found at this web page:
http://www.karger.ch/bookseries/wrund/wrund084.htm. The book is a compilation of articles showing how humanity's genetic makeup has been directly influenced by nutritional selective pressures and how our present day diet may be discordant with our stone age genome. The book is rather expensive and very technical and scientific in its language, but the description on the page is worth reading.
Date: Sun, 16 May 1999 16:05:32 GMT
Here's a roundup of what CCFA is featuring on their site, http://www.ccfa.org:
* CLINICAL TRIAL ALERT: An ongoing clinical trial is enrolling patients to test an experimental drug as a treatment for Crohn's disease. The drug is called ISIS 2302. It is being developed by Isis Pharmaceuticals, a biotechnology company pioneering in a new area of drug discovery called antisense-technology. ISIS 2302 works through an antisense mechanism. This drug works at the genetic level to inhibit the production of proteins that plays a role in Crohn's, as well as other inflammatory diseases. That protein is called ICAM-1. More information can be found at:
* THE 1999 CCFA RESEARCH REPORT: A researcher once said that studying Crohn's disease and ulcerative colitis is "like looking for a needle in a haystack." Actually, it's more like looking for several needles, in haystacks of all shapes and sizes. But, we have made great strides in the past decade. A hypothesis is forming to explain inflammatory bowel disease (IBD). Check out this story at:
Visit the Weekly Features section at: http://www.ccfa.org/weekly/ to view all the parts of the research report. (Some parts have yet to be posted, but will be posted in the coming weeks).
From: "paulah" <firstname.lastname@example.org>
Date: Sat, 20 Mar 99 19:06:30 PST
From: Sarah Krein <email@example.com>
Subject: Crohn's Disease on Increase
The results of a retrospective study of the incidence of
paediatric IBD over an 11 year period have recently been made public.
These findings are in direct contract to figures published in mid-80s on children in Scandinavia. The annual incidence of crohns disease was only 2.5 per 100,000 per year, but the incidence of UC was much greater than 4.3 per 100,000 per year. In Norway and Sweden, the incidence of UC was greater than that of CD. The reasons for such a variation in the incidence of CD in some areas is unknown.
In 1993, the prevalence of CD in the childhood population of Wales was 16.6 per 100,000 and of UC, 3.42 per 100,000.
News Updates at the Crohn's & Colitis Foundation of America: "Progress in IBD - Under The Microscope" http://www.ccfa.org/news/previous/news0319.htm
Date: Mon, 15 Mar 1999 21:50:35 -0500
From: Tina Guarasci <firstname.lastname@example.org>
Subject: searching journal articles
For those of you who are interested in searching through journal articles
for the latest research being done on IBD and related issues, the following
address allows you to search through Medline (a database of published
articles) for free.
Date: Sun, Mar 7, 1999, 11:21:33
From: Diane Mathison
To: Mik Aidt
Subject: Re: RE: Infectious Microbes Under Suspicion
An interesting article recently describes Giardia as being "the only common primary infection causing chronic malabsorption", and "Giardia is perhaps the most common cause of chronic malabsorption in North America". It also says that a Giardia infection causes a "celiac-like syndrome".
Date: Thu, 4 Mar 1999 19:31:50 -0600
Subject: Re: digestive diseases / bacteria (Off-Topic)
Dr. Mirkin, of the radio show, suggests treatment of Crohn's as though it were caused by bacteria, saying that the body would not be so stupid as to attack itself. Here's a link: http://www.wdn.com/mirkin/7107.html
There are other links as well.
Date: Wed, 03 Mar 1999 15:23:02 +0100
From: Mik Aidt
Subject: Infectious Microbes Under Suspicion
On the front page of the International Herald Tribune,
Tuesday, March 2, 1999,
an article titled "Can a Person 'Catch' Heart Disease? Maybe -- Infectious
Microbes Under Suspicion" states that a growing number of scientists believe
that many illnesses long presumed to have roots in genes or lifestyle might be
caused largely by infectious agents.
The full article can be found (this week only) on this webpage:
Date: Wed, 03 Mar 1999 07:29:03 -0800
Subject: Re: Infectious Microbes Under Suspicion
The press is finaly getting the message. Now if the medical bunch could just admit that they were wrong for a change.
Similar story in the Washington Post on March 1.
Date: Fri, 19 Feb 1999 12:00:57 -0500
From: "John Vazquez" <JVazquez@summsoft.com>
Subject: interesting website
This cousin of mine who is a veterinarian told me about this website that discusses the possible link between Crohns and the Mycobacterium Paratuberculosis.
Check it out it is very interesting.
Also, I have been on the diet for almost 7 months now and I appear to be in complete remission, I have no symptoms at all, and I have put on over 23 pounds, I actually have to start watching that I don't eat too much.
Date: Thu, 4 Feb 1999 12:28:01 -0600 (CST)
From: Roy deCarvalho <email@example.com>
Subject: News about new germ theory
News worth reading about germs (they are just realizing we were right):
Date: Fri, 29 Jan 1999 19:59:50 +0100
From: firstname.lastname@example.org (mik aidt)
Subject: Fiber, Sugar and the Risk of Colorectal Cancer
Hi everyone in the group,
I came across an article, "Dietary Fiber and the Risk of Colorectal Cancer and Adenoma in Women", in the last issue of The New England Journal of Medicine (January 21, 1999, Volume 340, Number 3) which I find interesting in regard to Gottshall's and Lutz's findings of the many negative effects sugar has on our bodies.
This is a quote from the editorial of the issue which is entitled "Fiber and Colorectal Cancer -- Where to Now?": "Is it really a surfeit of sugar, not an absence of fiber, that causes the risk of colorectal cancer to increase? Somewhat ignored, sugar consumption is consistently associated with the risk of colorectal cancer, and in a dose-response fashion. Perhaps a high intake of calories, aberrant responses to carbohydrates, and a lack of physical activity are also relevant."
This being said in regard to cancer, not to colitis. However, concerning sugar as well as physical activity, these new findings are - as far as I can see - confirming why we SCD'ers are on the right track.
In Denmark, results of another survey were published recently, stating that scientists now have evidence that four hours of exercise a week (approx. half an hour a day) has a significant effect on the healing process for patients with colon cancer.
The New England Journal of Medicine article summary and editoral can be found at:
Date: Wed, 11 Nov 1998 09:39:46 -0500
From: "Serge, Luba" <email@example.com>
Subject: JAMA & alternative medicine
Some interesting articles from the JAMA (The Journal of the American Medical Association) on alternative medicine. What do you think, is this a sincere interest in alternatives or are they realising that they are loosing their prestige and missing out on lucrative practices?
(mother of Lara, CD)
Date: Mon, 02 Nov 1998 00:48:31 +1000
From: Phillips <firstname.lastname@example.org>
Subject: Re: Entecort off-topic
> I have been surfing the net trying to find more information on Entecort made
> by Astra also known as budesonide.Claudette had mentioned she might have some
> info. I am very interested and will be willing to go to any lengths to get it
> (even take Chanelle to Canada to a Dr. there as it is not available in the
> U.S.) We are on our third attempt to get her off prednisone and God willing we
> will succeed time but if not we have to find a safer alternative because of
> the long term side effects of the pred. Any leads will be greatly appreciated
> Jill UC
Did you see the posting on "Infliximab"?? It's something new that just got
approved in the states. It's what I'm trying to get my doctor to prescribe to
me. I don't like the side effects of prednisone and the Pentasa is not doing
everything I need it to do. Infliximab (also known as Remicade) has only a few
side effects, IF you get any side effects at all, and it's an injection....not
like a continuous pill taking escapade that I endure now. It is a combination of
human and mouse (watch out for those unusual cravings for cheese and unexplainably
sudden fear of cats (I'm kidding!!)), antibodies that bind to something in your
body that causes the inflammation. It doesn't supress your immune system...which
was the next thing on my list to try (immunosupressants). I'm not sure what the
web page address is, but if you use a search engine and look up "Infliximab" or
"Remicade" it should turn up something. The other downside...it is a little
expensive, but no more I suppose then all the pills....hope it helps.
Peace & Protect....
Date: Thu, 08 Oct 1998 07:16:29 -0800
From: "Ben Montag" <email@example.com>
I was just reading the CCFA site. There is an article that Bayer Corp. is
initiating a study of Ciproflaxin (an antibiotic) for treating Ulcerative
Colitis. The signifigance to us is the study is prompted by the conclusion
that "a number of intestinal pathogens (e.g., bacteria) are associated with
relapses of ulcerative colitis, and may act as triggering factors."
Though this is not the direction we would like to see research go, this does
give us all ammunition when we are in discussions with skeptical
gastroenterologists that there is a bacterial cause to our disease.
Fra: Crohn's & Colitis Foundation of America
Emne: CCFA WEB SITE UPDATE
Dato: 28. august 1998 20:31
Greetings from CCFA! Here's an update of recent stories and new sections
you'll find on our Web site, at http://www.ccfa.org :
** As you may know, our big story this week was the approval of
Remicade+, a new drug for Crohn's disease. You can find the story at
** Speaking of Crohn's, there have also been some new findings on the
drug budesonide: http://www.ccfa.org/news/news821.htm
** Here's a topic we're all interested in: the intimate relationship of
sex and IBD. Look out, Dr. Ruth! http://www.ccfa.org/weekly/wkly731.htm
Date: Thu, 08 Oct 1998 14:58:27 -0800
From: "Ben Montag" <firstname.lastname@example.org>
Subject: chat-medical references
The best medical overview of Crohn's disease and Ulcerative Colitis I have
found is Crohn's Disease and Ulcerative Colitis by Dr. Fred Saibil. It is an
excellent reference of what the diseases are and what treatments are
available. However, he does not deal with the SCD diet or alternative
medicines at all. The book can be bought at Amazon.com. There are also
plenty of reviews there to judge for yourself.
Date: Sat, 03 Oct 1998 12:28:22
From: T G <email@example.com>
Subject: Diet and Chrohn's article
I thought some people might be interested in a recent review article that
I've found. So far I have only read the abstract, but I will be getting
the article to read soon.
The reference is: Nutritional therapy in Crohn's disease.
Inflamm Bowel Dis. 1998 Feb;4(1):45-53. Review.
Here is a copy of the abstract:
"The value of nutritional support in the prevention and treatment of
malnutrition in Crohn's disease is undisputed but its role in
primary therapy continues to be debated. Controlled trials have
demonstrated that enteral nutrition induces remission rates
comparable to that of corticosteroid therapy in Crohn's disease and remains
the treatment of choice for specific subgroups such
as children with signs of growth impairment and patients with intolerable
steroid-induced side effects. The mechanism by which
an enteral diet induces remission in Crohn's disease is unclear. Bowel
rest, reduced antigenic load, nutritional effects, the
provision of trophic amino acids, modification of gut flora, intestinal
permeability, or fecal pH have been proposed. Equally, the
fat profile of the feed may reduce pro-inflammatory ecosanoid synthesis and
thus modify disease activity. Maintaining long-term
remission remains a challenge in the management of this disease. Cyclic
administration of enteral diets, maintenance drug
therapy, fat manipulated formulas, or fish oil therapy may be strategies to
prolong diet-induced remission. In the future, nutrient
derivatives that play a role in the protective processes of the intestinal
mucosa may have application in nutritional therapy in
Crohn's disease. "
Date: Mon, 05 Oct 1998 09:29:36 -0400
From: T G <firstname.lastname@example.org>
I will try to clear up the issue of what exactly the people in the study on
diet and Crohn's were eating when I get my hands on the actutal article.
Unfortunately, the library at the University here does not carry it, so I
will have to do some looking around.
The thing I found most significant about the abstract was the statement
that these type of diets might work because of their effect on gut flora.
Since this is what we are doing with our diet, I thought it was important
that a study out there actually recognized that fact.
Date: Thu, 1 Oct 1998 11:00:11 -0700
From: "Benke, Anna" <BenkeA@pac.dfo-mpo.gc.ca>
To: "Ibdlist (E-mail)" <email@example.com>, "SCD (E-mail)"
Subject: Scientists isolate immune system 'on/off switch'
07:42 AM ET 09/29/98
Scientists isolate immune system 'on/off switch'
By Jonathan Birt LONDON, Sept 29 (Reuters) - Scientists have isolated a
which they believe acts as an on/off switch for the body's
immune system, promising new ways of treating conditions ranging
from cancer to Crohn's Disease, the British company behind the
breakthrough said on Tuesday.
Researchers at the U.S. arm of Chiroscience Group Plc are
also close to locating a second gene which could reverse bone
wasting caused by osteoporosis, a condition which affects
millions of people over 60 and leads to more than one million
fractures in the U.S. every year.
Research and Development Director Robert Jackson said
uncovering the gene which regulates the body's immune response
could one day lead to development of a whole new range of drugs.
''Sometimes you want to turn it off and sometimes you want to
turn it on,'' Jackson told Reuters.
Turning the immune system on or up could help in conditions
like AIDS and cancer, where the body's efforts to fight off
tumours are currently too weak.
''If we could strengthen that, we could develop drugs to
help the body react to tumours,'' Jackson said.
But switching it off or down might be useful in a range of
diseases caused by an overly fierce immune response -- such as
rheumatoid arthritis, diabetes, psoriasis, Crohn's Disease,
ulcerative colitis and allergy.
Gene-based research at the former Darwin Molecular
in Seattle, Washington, which Chiroscience bought in 1996, is
also close to locating a mutant gene which may offer a way of
reversing the effects of osteoporosis for the first time.
Scientists are studying around 100 people and their
in South Africa with extremely strong bones caused by a mutant
gene which causes bone density to increase as people age -- the
exact opposite of osteoporosis.
''We are close to identifying a unique bone structure gene
for osteoporosis,'' Chief Executive Officer John Padfield told
''All other treatments try to stop bone loss getting
What our gene appears to do is increase bone density very
substantially -- if this turns out to be true when we test a
drug, that would be a revolutionary treatment for
The company announced the discoveries as part of a
update on its research and development activities. Shares in
Chiroscience were up seven percent or 17 1/2 pence in early
afternoon trading in London.
Chiroscience said it will also work with the small British
genome company Gemini Research, which has built up a database of
genetic information based on identical twins. The two companies
are to look for mutant genes linked to obesity.
Date: Mon, 24 Aug 1998 17:48:06 -0500
From: "Bixler, Cindy" <firstname.lastname@example.org>
To: "'SCDemail@example.com'" <SCDfirstname.lastname@example.org>
Subject: RE: Infliximab
> -----Original Message-----
> From: macneil [SMTP:email@example.com]
> Sent: Monday, August 24, 1998 4:36 PM
> To: SCDfirstname.lastname@example.org
> Subject: infliximab
> On our news today there was an item re a new drug called Infliximab which
> just received FDA approval in the US for the treatment of Crohn's.
> Apparently it is a radical new treatment as it neutralizes an antibody
> attacks the protein involved in Crohn's.
> If anyone comes across info regarding it could you send it to me?
> I'm in Canada so info on it is scarce so far.
> -I wonder if it also helps UC.
Here is the article...
Crohn's Disease Drug Approved
About 400,000 Americans have Crohn's disease, a severe gastrointestinal
tract inflammation that causes diarrhea, abdominal pain, fever and
The Associated Press
W A S H I N G T O N, Aug. 24 - The Food and Drug Administration today
approved a revolutionary treatment for the debilitating bowel disorder
Crohn's disease: A biologically engineered antibody that attacks a
protein responsible for much of patients' misery.
Centocor Inc.'s infliximab is a part-human, part-mouse antibody, to be
sold under the brand name Remicade.
About 400,000 Americans have Crohn's disease, a severe gastrointestinal
tract inflammation that causes diarrhea, abdominal pain, fever and
weight loss. In severe cases, patients develop intestinal blockages and
ulcer-like channels called fistulas that burrow through the bowel wall.
It mostly strikes women, usually between ages 20 and 35. There is no
cure. Most patients are treated with steroids to reduce the
inflammation; some require repeat surgeries to remove damaged parts of
Remicade is a monoclonal antibody, a biologically engineered drug that
sweeps through the body hunting down and neutralizing tumor necrosis
factor, a protein that causes much of the intestinal inflammation.
In a study of 108 moderate to severe Crohn's patients, 82 percent who
received an injection of Remicade improved, including 48 percent who
went into remission. That compares with 16 percent of patients who
improved while taking a placebo.
Heals Fistula Sores
In the worst-case patients, Centocor says Remicade is the first medicine
documented to heal open fistulas: 68 percent had at least half of their
ulcer-like sores close during therapy, vs. 26 percent of patients who
received dummy injections.
But the benefits wear off: patients benefited most within the two to
four weeks after a single dose, the government said, and the percentage
of patients who saw benefits then fell over the next few months.
As part of the drug's approval, Centocor agreed to study whether the
drug also works over a longer time period, and whether it is safe for
long-term use, the government said.
Side effects included hives, shortness of breath or reduction of blood
pressure during the drug's infusion. Patients also may suffer nausea,
fatigue and infection, the company warned.
Centocor says pharmacies should have supplies of Remicade in early
October. A price was not immediately announced. Patients may also know
the drug as Avakine, the name Centocor first used when testing it.
Date: Tue, 11 Aug 1998 13:45:17 -0400
From: "Serge, Luba" <email@example.com>
Subject: OFF TOPIC (UK - milk and Crohn's disease)
The link between milk, mycobacterium paratuberculosis & Crohn's disease
seems to be hitting the news in the UK today. Just a bit came over the
radio here but the BBC seems to have good coverage. Thought it might be of
Date: Sun, 02 Aug 1998 13:09:12 PDT
Date: Mon, 10 Aug 1998 12:02:58 -0400
From: Midas Gold <firstname.lastname@example.org>
To: SCDemail@example.com, SCD@MAELSTROM.STJOHNS.EDU
Subject: A Gut Feeling
For anyone who's interested, here is an IBD/gut bacteria thesis that
draws strikingly different dietary conclusions than does Elaine
Gottschall in _Breaking the Vicious Cycle_.
(Also placed here)
Date: Sun, 2 Aug 1998 13:09:12 PDT
From: C Smith <csmithz@HOTMAIL.COM>
Subject: News about ISIS Drug trial
This was released by ISIS pharmaceuticals on June 10, 1998
via the PR Newswires (actually for stock holders)
Isis Crohn's Disease Drug Shows Evidence of Durable Remission,
Steroid-Sparing And Fistula Healing Effects
Results of Phase II Trial Show Inhibition of ICAM-1 and Other
Supporting Antisense Mechanism
CARLSBAD, Calif., June 10 /PRNewswire/ -- In the June 1998 issue of
Gastroenterology, Isis Pharmaceuticals (Nasdaq:
ISIP - news) and Crohn's disease academic researchers report on the
results of a well-controlled 20-patient Phase II trial of
ISIS 2302 in the treatment of Crohn's disease. These results show a
statistically significant lowering of steroid requirements
(p=0.0001) in ISIS 2302-treated patients, and show that by the end of
the one month treatment period, ISIS 2302 produced
disease remission (Crohn's Disease Activity Index <150) in 47% of
patients treated with the drug. The mean duration of
remission was prolonged; at the end of the 6-month trial, 5 of the 7
ISIS 2302-treated remitters were still in remission following
a single course of treatment. In addition, at the end of 6 months,
corticosteroid treatment was completely discontinued in 33%
(5 of 15) of the ISIS 2302 treated patients and in no placebo patients.
Long-term steroid use can cause severe side effects
including osteoporosis, immune suppression and endocrinological changes.
This publication includes data on the 20-patient, double-blinded,
placebo- controlled, randomized (3:1; ISIS 2302: placebo)
Phase II trial which were previously presented at two scientific
conferences, as well as data supporting that ISIS 2302 is
working through an antisense mechanism.
The publication is entitled, ''A Placebo-Controlled Trial of an ICAM-1
Antisense Oligonucleotide in the Treatment of Crohn's
Disease.'' The authors are Bruce R. Yacyshyn, M.D., Mary Beth
Bowen-Yacyshyn, Ph.D., Lawrence Jewell, M.D., of the
Department of Gastroenterology, University of Alberta, Edmonton; Joseph
A. Tami, Pharm.D., C. Frank Bennett, Ph.D.,
Daniel L. Kisner, M.D., and William R. Shanahan, Jr., M.D., of Isis
ISIS 2302 is an antisense inhibitor of intercellular adhesion molecule
-1 (ICAM-1), a cell adhesion molecule implicated in a
wide range of inflammatory diseases and conditions. The drug is a key
asset in the cell adhesion collaboration between Isis and
Boehringer Ingelheim GmbH. A 300-patient pivotal quality trial of ISIS
2302 in patients with steroid- dependent Crohn's
disease is underway in North America and Europe.
Two patients who had an open fistula when they entered the study and
were treated with ISIS 2302 experienced healing of
their fistula. Fistulae are open channels from the bowel to the skin and
other organs through which fecal matter can drain,
causing soiling, pain and infection. In addition, both patients in this
study with gastroduodenal Crohn's disease (located where
the stomach meets the intestine) were treated with ISIS 2302, and both
experienced resolution of upper gastrointestinal
obstructive symptoms during the course of treatment. These two patients
remain free of their obstructive symptoms after over
one year following treatment with ISIS 2302.
''The ability of ISIS 2302 to produce durable remissions in patients
with steroid-dependent Crohn's disease, to heal fistulae
and to reduce and, in many patients, eliminate steroid use, strongly
suggests that ISIS 2302 can be an important treatment for
Crohn's disease,'' said Bruce R. Yacyshyn, M.D., Division of
Gastroenterology, University of Alberta, Edmonton, and lead
author on the paper.
Antisense Mechanism Supported
Newly released findings reported in the Gastroenterology article suggest
a strong correlation between treatment with ISIS
2302, reduction in ICAM-1 expression in affected bowel tissue and
apparent release of proinflammatory lymphocytes from the
gut. In the intestinal mucosa of patients treated with ISIS 2302,
decreases in ICAM-1 expression (CD54) were seen in
significantly more of the ISIS 2302-treated patients than
placebo-treated patients, and higher doses of ISIS 2302 produced
greater effects. In addition, an increase in peripheral blood T-cells
bearing the adhesion molecules alpha-d and beta-7, which
are involved in lymphocyte homing to the intestine, was observed. The
correlation of ICAM-1 inhibition and the apparent
release of immune cells from the intestine suggest that suppression of
ICAM-1 results in an interruption of the immune cell
intestinal trafficking and retention that are critical to the
perpetuation of the inflammatory disease process. This interruption may
allow restoration of normal bowel mucosal integrity and immune function,
thereby resulting in prolonged disease suppression.
''In patients treated with ISIS 2302, the changes observed in peripheral
blood lymphocyte and intestinal mucosal expression of
adhesion molecules strongly suggest a therapeutic effect with ISIS 2302
achieved through an antisense mechanism of action.
These data provide the first evidence of an interplay in inflammatory
disease between specific cell adhesion molecules, with
potential implications for designing antiinflammatory drugs in the
future,'' said Dr. Yacyshyn.
This press release contains forward-looking statements concerning the
therapeutic potential of ISIS 2302, an antisense drug in
development for Crohn's disease and other inflammatory disorders. Such
statements are subject to certain risks and
uncertainties, particularly those inherent in the process of
discovering, developing and commercializing drugs that are safe and
effective for use as human therapeutics. Actual results could differ
materially from those projected in this release. As a result,
the reader is cautioned not to rely on these forward-looking statements.
These and other risks concerning the therapeutic
potential of ISIS 2302 are described in additional detail in Isis'
Annual Report on Form 10-K for the year ended December
31, 1997 and in the company's most recent quarterly report on Form 10-Q,
which are on file with the U.S. Securities
Exchange Commission, copies of which are available from the company.
Isis Pharmaceuticals, based in northern San Diego County, is engaged in
the discovery and development of novel human
therapeutic compounds. Isis has six compounds in human clinical trials:
fomivirsen, to treat CMV-induced retinitis in AIDS
patients, has completed Phase III clinical trials and an NDA has been
filed; ISIS 2302, an inhibitor of ICAM-1, is in a pivotal
quality trial for Crohn's disease, Phase II clinical trials for renal
transplant rejection, rheumatoid arthritis and ulcerative colitis,
and is being explored as a topical administration for psoriasis and an
aerosol administration for asthma; ISIS 3521/CGP
64128A is in Phase II trials as a treatment for cancer; ISIS
5132/CGP69846A is in Phase II clinical trials as a treatment for
cancer; ISIS 2503 is in Phase I trials as a treatment for cancer; and
ISIS 13312 is in Phase I/II clinical trials for the treatment of
CMV retinitis in AIDS patients. The company also has several additional
compounds in preclinical development. Isis' broad
medicinal chemistry and biology research programs support efforts in
both antisense and combinatorial drug discovery.
2292 Faraday Avenue
Carlsbad, CA 92008
Does anyone know about the current trial that ISIS
It's up to the FDA to approve it and from the
Yahoo stock board (quote.yahoo.com) and the stock
ticker (ISIP) I found messages claiming FDA
approval is due October this month....?
Can someone please check with FDA ? This drug
could change lives
C Smith <csmithz@HOTMAIL.COM>
Date: Sat, 18 Jul 1998 14:03:51 -0400
From: "Claudette Cameron" <firstname.lastname@example.org>
Subject: re Entocort
Just thought I would let you know that I have found some information re the
drug Entocort.It is a new drug specifically for Chron sufferers which has
been recently approved by Health Canada.If you are interested in finding
out more, go to http://pslgroup.com/dq/22e9e.htm
My grandson has recently been removed from prednisone and has started the
Date: Thu, 16 Jul 1998 12:59:49 -0400
From: Midas Gold <email@example.com>
Subject: Mycobacterium Paratuberculosis, CD, and Pasteurized Milk
Anti-Milk Group Exposes Claim That Normal Pasteurization Kills
Dangerous Bacterium in Milk
Tuesday, July 14 9:07 AM ET
AntiDairy Coalition Faults FDA and USDA for Misinterpreting Scientific
NEW YORK (BUSINESS WIRE) - The AntiDairy Coalition has denounced a
claim, based on a recent U.S. Department of Agriculture (USDA) study,
that normal pasteurization practiced by dairy producers nationwide
inactivates a dangerous bacterium routinely found in raw milk.
In his weekly AntiDairy Coalition Newsletter column on the Internet,
Coalition executive director Robert Cohen says the USDA study, which
was reported in the May 10, 1998 issue of Hoard's Dairyman, a trade
publication, has been completely misrepresented by the agency and by
the Food and Drug Administration (FDA) in claiming that normal
pasteurization (72 degrees centigrade for 15 seconds) destroys
mycobacterium paratuberculosis, the bacterium linked to Johne's
disease in cows and Crohn's disease in humans that produces persistent
and severe diarrhea.
Cohen, author of "Milk - the Deadly Poison," says that the USDA study
actually revealed that the dangerous bacteria were not totally
inactivated until after 15 minutes of pasteurization at 72 degrees
That's "very bad news for all milk drinkers," says Cohen. "Normal
pasteurization at this temperature calls for only a 15-second
treatment, not 15 minutes. We believe the government and Hoard's
Dairyman are misleading the public into thinking pasteurized milk is
safe from mycobacterium paratuberculosis when the USDA's own scientist
is saying that pasteurization inactivates the bacterium only when the
process maintains at least 72 degrees centigrade for at least 15
minutes. That's 14 minutes and 45 seconds longer than the normal
commercial pasteurization of milk in the United States."
The USDA study is entitled "Heat Inactivation of Mycobacterium
paratuberculosis in Raw Milk: Are Current Pasteurization Conditions
Effective?" Based on this study, Hoard's Dairyman told its
100,000-plus milk producer subscribers, "Heat treatment
(pasteurization) destroys this dangerous disease."
Cohen says the FDA supports the same conclusion. He refers to a letter
addressed to government officials from Joseph Smucker, team leader of
the Milk and Safety Team at the Center for Food Safety and Applied
Nutrition, a branch of the FDA. The letter says: "After a review of
the available literature on the subject, it is the position of FDA
that the latest research shows conclusively that commercial
pasteurization does indeed eliminate this hazard."
Cohen says every assertion about pasteurization's effectiveness is
refuted in the abstract of the USDA study, which states: "Currently,
it is not known whether commercial pasteurization effectively kills
mycobacterium paratuberculosis in contaminated raw milk."
"This sentence," Cohen says, "contradicts every conclusion made from
this very same paper!"
The senior author of the abstract is Judy Stabel, Ph.D. On the second
page of Dr. Stabel's paper (published in the December 1997 issue of
Applied and Environmental Microbiology), she reveals: "Bacteria were
not totally inactivated until after 15 minutes of incubation
(pasteurization) at 72 degrees centigrade."
In her paper, Dr. Stabel also writes: "There is no definitive evidence
to date that viable M. paratuberculosis is present in retail
pasteurized dairy products."
When she was asked why there was no evidence and if milk samples had
ever been tested at retail sites, Cohen says her response was "No."
When asked "Why not?" she replied, "I don't know."
However, Cohen contends that British scientists have taken milk
samples at the point of retail purchase and have cultured live
tuberculosis bacteria from these samples.
Cohen concludes that the FDA and USDA have misinterpreted Dr. Stabel's
paper, and scientific evidence suggests that this dangerous bacterium
survives pasteurization. "This is just another example of how
Americans are being betrayed by regulatory agencies like FDA and
USDA," Cohen warns.
Formed in June 1998, the AntiDairy Coalition includes some of the
country's top physicians and health educators: Dr. Julian Whitaker,
author and editor of the monthly newsletter, Health & Healing; Dr.
Charles Attwood, often called heir apparent to Dr. Benjamin Spock; Dr.
Vicki Griffin; Dr. Daniel Twogood; Dr. Richard DeAndrea and Dr.
This release is available on the KCSA Public Relations website at
Contact: KCSA Worldwide, New York Jennifer Urezzio, 212/896-1223
Date: Tue, 14 Jul 1998 10:06:49 -0700
From: David Hyde <dhyde@CCSF.CC.CA.US>
Subject: diet linked to colon cancer
Monday July 13 6:23 PM EDT
Western diet linked to colon cancer risk
NEW YORK, Jul 13 (Reuters) -- Diets rich in meat and low in fruits and
vegetables may increase the risk of colon cancer,
concludes a report.
"The dietary pattern associated with the greatest increase in risk is
the one which typifies a Western-style diet," say researchers
led by Dr. Martha Slattery of the University of Utah Medical Center in
Salt Lake City.
According to the American Cancer Society, colon cancer kills over 46,000
people every year in the United States, making it
the country's second leading cause of cancer death, after lung cancer.
Experts have long speculated that certain foods and diets
may influence colon cancer risk.
In their study, published in the current issue of the American Journal
of Epidemiology, the investigators used detailed
questionnaires to ascertain the long-term eating patterns of nearly
4,400 American adults. Half of those interviewed were colon
cancer patients, while the other half were healthy "controls."
Men and women who ate what the researchers labeled a "Western" diet --
high in red and processed meats, refined grains and
sugars, and low in fresh fruits and vegetables -- doubled their overall
risk for colon cancer. This type of diet was also strongly
associated with higher daily cholesterol and energy intake, weight gain,
In contrast, individuals who stuck to what the researchers labeled a
"prudent" diet -- low in red meat and sugars but high in
fish, poultry, fresh fruits and vegetables -- achieved a nearly 40%
reduction in their colon cancer risk. These individuals also
exercised more and had an average lower body weight than those on more
A third type of diet, where individuals substituted whole grains for
processed grains, poultry for red meat, and margarine for
butter, provided about a 15% reduction in risk, but statistical analysis
shows that this difference may have occurred by chance.
The researchers point out that these 'substituters,' "while adopting
many healthy eating patterns, did not include vegetables as
part of their dietary pattern and (therefore) did not experience the
reduced risk of colon cancer observed in those with the
Slattery and her colleagues believe the study "lends further support to
the commonly held belief that a Western-style diet
contributes to colon cancer risk and that a prudent diet, one enriched
with vegetables, refined grains, fruits, fish, and poultry,
may help prevent colon cancer." SOURCE: American Journal of Epidemiology
Office of Research and Planning
City College of San Francisco
50 Phelan Ave.
San Francisco, CA 94112
In Infection and Immunity's (published by American Society for Microbiology) November issue, Vol. 65, No. 11, 1997, page 4476-4482, you can read an article about some of the latest findings concerning the "V antigen" - a protein which can turn out to be a powerful weapon against infectious diseases like Crohns and Colitis.
The article is entitled: " Regions of Yersinia pestis V Antigen That Contribute to Protection against Plague - Identified by Passive and Active Immunization" and the research was carried out in England by Jim Hill, Sophie E. C. Leary, Kate F. Griffin, E. Diane Williamson, and Richard W. Titball at the Microbiology departmanet at CBD Porton Down in Salisbury, Wiltshire SP4 OJQ.
At St. Bartholomew's Hospital in England, the V antigen is presently being tested on Colitis patients.
In November 1997, over 2,500 gastroenterologists gathered in Chicago for the American College of Gastroenterology's 62nd Annual Scientific Meeting to discuss the latest scientific advances in GI research, treatment of digestive diseases and clinical practice management. Read the introductory paper her:
NEW SCIENTIFIC ADVANCES IN GASTROENTEROLOGY PRESENTED AT COLLEGE'S 62ND ANNUAL SCIENTIFIC MEETING
Some of the headlines were:
Article on Enzyme Potentiated Desensitization.
Lists Crohns and other IBD/IBS diseases as being something that has been successfully treated with Enzyme Potentiated Desensitization.
Date: Wed, 26 Nov 1997 11:39:28 +0000
From: Keith Monroe <keith.monroe@MCMAIL.COM>
Subject: Dysbiosis article
I now have an electronic version of the article on intestinal dysbiosis and I have permission to distribute it to people on this group. If anybody would like a copy, please send me an email. I could post the whole thing, but it's about seven pages long so I wouldn't want to waste space if only a few people are interested.
Here's an introduction to the article:
"With the advent of biochemical and microbial stool analysis panels, an increasing number of physicians are seeking a clearer understanding of the relationship between the ecology of the digestive tract and local and systemic factors affecting health and disease. It can be described as being due to either putrefaction, fermentation, deficiency, or sensitization. A number of inflammatory diseases within the bowel or involving skin and connective tissue have been reported in association with dysbiosis. This article details the relationships, causes, and treatment options for dysbiotic-related conditions."
4 August 1997
MedPulse is Medscape's email newsletter informing registered members of new content posted on the world's leading medical Web site.
Crohn's disease has features in common with Johne's disease, an intestinal infection of animals caused by Mycobacterium paratuberculosis. Molecular biologic techniques have been used to find a link between Crohn's disease and mycobacteria, but these studies have yielded conflicting results so far.
[Infect Med 14(7):569-573, 1997]
READ THE FULL-TEXT ARTICLES ON THE WORLD WIDE WEB at:
Link to article may be found at:
Date: Fri, 25 Jul 1997 18:22:45 -0700
From: Dempsey <stellar1@PACBELL.NET>
Subject: Bowel Disease and Diet
Here is an excellant article on reactive bowel disease and diet. There are a few references in it that back up Elaine's hypothesis for the elimination of dairy and cereal grains. For example:
"In a study by V. Alum Jones et al, 67% of patients with IBS improved after one week on a strict diet. The GIT disturbance was related to increased levels of Prostaglandin E2 and not related to IgE-mediated hypersensitivity. Nanda et al implicated dairy products and cereal grains in IBS; almost half of the 200 patients were treated with diet revision, and almost half improved. Pagenelli showed similar improvement on a restricted diet and increased GIT permeability to beta-lactoglobulin was demonstrated in 3 patients using serum measurements with a sensitive immunoradiometric assay after milk challenge. Circulating immune complexes after challenge with milk were demonstrated in 9 of 13 patients before diet revision. The addition of cromolyn sodium ( Nalcrom), a mast-cell stabilizing agent, improved symptom remission in some patients."
Mon, 7 Jul 1997 9:34:03 GMT
I found an article on "Current Medical Therapy for Inflamatory Bowel
Disease" on the net lately
(Full text under: http://www.sma.org/smj/96jun2.htm).
Especially the part on "Short-Chain Fatty Acids" (see below) aroused my
interest. Does anyone of you know a brand name of such a medicament?
Pharmacists and doctors here haven`t heard of it at all.
"Short-Chain Fatty Acids
Short-chain fatty acids (SCFA), especially butyrate, are the preferred
energy substrate for distal colonic epithelial cells. Decreased fecal
concentrations of SCFA have been shown to occur in patients with
ulcerative colitis but not Crohn's colitis. Table 3 summarizes clinical
studies on the use of SCFA enemas for active distal ulcerative colitis.
The clinical response rates of 56% to 90% are slightly lower than those
reported for hydrocortison or mesalamine enemas. The uniqueness of SCFA
therapy is that the presumed mechanism of action is feeding the colon
rather than altering its immune response. SCFA therapy given
concurrently with other agents might offer even more promise. In fact,
one small uncontrolled trial reported a 100% response rate using a
combination SCFA/5-ASA enema therapy in patients with previously
refractory distal ulcerative colitis."
Tue, 8 Jul 1997 0:07:32 GMT
Hi, Miroslav. I've been trying to find out about this, too, without much
success (haven't had too much time). I also came across a paper that said
they were studying aloe vera for SFA's. SFA's (like butyric acid) are also
produced in a normally-functioning bowel from enzymes working on fibre.
D. Hartl RMT
Re: MedLine Search confirms link between High Carbohydrate In...
Sat, 12 Jul 1997 11:09:50 GMT
I would like to make a supplement to this:
>In a recent IBDlist digest, someone mentioned the free MedLine link at
>the National Institute of Health's National Library of Medicine, at
I am using Medline as often as possible and did find another interesting article recently:
Martini & Brendes:
Increased Consumption of Refined Crabohydrates in Patients with CD.
Klin. Wschr. 54, 367-371 1976.
Conclutions from reading:
There was an significant difference in intake of refined suger between 63
patients and a control group of 63: 482 gram/week against 285 gram/week.
Before the disease was recognized the patients consumed even greater amount:
Martini and Brandes suggests that: "It is possible that the increased
consumtion of suger for many years may lead lead to changes in the
intestinal bacterial flora and general milieu in such a way that the mucosa
may be damaged..."
This trial from 1976 (!) has certainly been IGNORED by school medicine.
Odd Oivind Bergstad
MedLine Search confirms link between High Carbohydrate Intake and IBD
Fri, 11 Jul 1997 18:36:36 GMT
In a recent IBDlist digest, someone mentioned the free MedLine link at the National Institute of Health's National Library of Medicine, at http://www.nlm.nih.gov/.
I followed the link to MedLine and did a search there on Carbohydrate and Diet and IBD. I found the following:
Eur J Gastroenterol Hepatol 7 (1): 47-51 (Jan 1995)
Dietary habits as risk factors for inflammatory bowel disease.
by Tragnone A, Valpiani D, Miglio F, Elmi G, Bazzocchi G, Pipitone E, Lanfranchi GA
Division of Internal Medicine, Bellaria Hospital, University of Bologna, Italy.
OBJECTIVE: To examine the influence of dietary factors in Italian patients with ulcerative colitis and Crohn's disease.
DESIGN: We studied dietary habits immediately prior to the onset of disease in 104 patients enrolled in a prospective, epidemiological study of the incidence of inflammatory bowel disease in Italy.
METHODS: Each patient was interviewed using a recall questionnaire to provide information on the daily intake of nutrients. The differences in diet between patients and healthy subjects matched for age, sex and city of residence were determined.
RESULTS: Our data confirm that patients with Crohn's disease and ulcerative colitis have a high intake of total carbohydrate, starch and refined sugar. This resulted in a significantly higher relative risk (P < 0.001) in both ulcerative colitis and Crohn's disease patients. Total protein intake was significantly higher in ulcerative colitis, but not in Crohn's disease patients, than in controls. Fibre consumption did not differ between patients and controls.
CONCLUSIONS: Our results confirm that carbohydrate consumption is significantly higher in IBD patients than in healthy controls. Ulcerative colitis patients also consumed more total protein than controls. The pathogenetic significance of these findings, however, remains unclear. ...
PMID: 7866810, MUID: 95171184
- Russ Johnson (Dallas, TX -- USA)
Fri, 4 Jul 1997 1:02:45 GMT
Two recently published papers provide solid evidence that Mycobacterium paratuberculosis is involved in at least a proportion of Crohn's disease. Crohn's disease is so similar to mycobacterial diseases that it is often confused with one of them, intestinal tuberculosis. Alan Kennedy maintains a very interesting web site on the subject: "Does Mycobacterium paratuberculosis cause Crohns disease?" -- a very thorough collection of material which suggest that Mycobacteria (paratubercolosis and avium) could be a possible cause of IBD.
(In 1991, the Department of Medical Microbiology, Bartholomew's Hospital, London, came to the opposite conclusion, which you can read more about here.)
Wed, 4 June 1997 23:56:12 GMT
Here is a new study that provides evidence that children with Crohn's disease have alterations in circulating antioxidant defenses, possibly related to an ongoing oxidant stress.
Sun, 11 May 1997 13:35:33 GMT
Hi SCD Group,
Some news from the Danish Colitis-Crohn Associations magazine:
The Danish Crohns-Colitis Association recently donated app. 11,000 US dollars for a research project which is to either confirm or kill the theory that there could be a relationship between the mycobacterium "Paratuberculosis" and Crohns.
This mycobacteria can possibly affect the human immune-defense system, triggering the infection in the intestines. Since it is a bacteria that grows very slowly, it doesn't "show up" when our doctors and scientists look for it with the standard test methods.
Two Danish doctors are going to join a professor from University of Wisconsin in Madison, USA, in researching, using a new DNA technology.
Also, Danish scientists are presently looking into the effect of yoghurt "lactobacilles" which - if used in large quantity - can heal a wound in a week.
Independent research supports SCD
[Re: independent research supports SCD]
Sat, 3 May 1997 7:11:55 GMT
Yes, except the SCD explicitly excludes FOS - Fructo Oligiosacharides.
A certain protein
Sun, 27 Apr 1997 17:07:43 GMT
I have the opportunity to be involved in a study being done here in Edmonton, Alberta Canada at the university Hospital. I talked to the research nurse and in very short terms what it involves is this: The research team has found that people with Crohn's/colitis are lacking a certain protein and when this protein is injected back into the body ( much like diabetics do with insulin), the bowel actually heals. I realize this is an extremely simplified explanation but my appointment regarding this is tomorrow morning, so as soon as I have more info I will pass it along. Regardless of
the outcome, I am going to stick with the diet as I truly believe it has the potential to heal just like this protein possibly does.
Tue, 7 Jan 1997 19:35:34 GMT
Thought you might be interested in this posting to the alt.support.crohns-colitis newgroup:
>All of y'all should know about the IBD Home Page run by Dr. R. Holland
>Please check it out at : http://dbts136.uicomp.uic.edu
>Many useful links and Ron has also astutely summarized much of the new
>information and conference proceedings.
There's info on encouraging results from use of heparin, an anticoagulant, for UC and Crohns.
Tue, 17 Dec 1996 00:34:40
This page updated on